The foods we consume every day contain fat, protein and carbohydrates. When we consume the carbs the sugar level raises and then they are transformed into glucose. The beta cells of the pancreas play an important role by secreting insulin that lets the glucose to enter the body’s cells, particularly in the liver thus being properly processed and stored.
If the body lacks beta cell in the pancreas, then in that case the glucose cannot process glucose properly. When such thing happens, then the affected person suffers from diabetes.
According to Daily Mail, researchers have managed to create a cocktail of drugs that support the multiplication of insulin-producing cells. This is the discovery that would cure diabetes. However, there are still researches needed about the use of this drug, but it is considered to be the new cure for diabetes that can treat both type 1 and type 2 diabetes.
As afore mentioned, diabetes occurs when there are not enough beta cells in the pancreas to produce insulin, or when the body cannot produce enough insulin. The body needs insulin so that to regulate blood glucose.
In the last decades this disease is spreading more and more, namely the estimation is that by the year of 2025 there will be approximately 300 million people suffering from diabetes in the whole world. The bad part about this disease is that it stays for a lifetime, and if it is not managed properly it can lead to serious health issues like stroke, heart disease, kidney damage, eye damage, and even vision loss.
Two Main Types of Diabetes:
Type 1 Diabetes
This type of diabetes is considered to be an autoimmune disease, and it is not as often as type 2 diabetes. Previously it was recognized as insulin-dependent diabetes in which the immune system identifies the beta cells as invaders and because of that eliminates them. Percentage wise, around 6% of diabetics are having this type of diabetes, and it commonly affects children, adolescents or young adults.
Type 2 Diabetes
This is the most common type of diabetes as 92% of diabetics have this type which mostly affects people over 40 years old. But, this has changed recently as young people start to have it as a result of overweight, obesity and not enough physical activity. The reason for its appearance is not enough beta cells which can lead to the appearance of type 2 diabetes.
As per the findings of Dr. Andrew Stewart, director of the Institute of Diabetes, Obesity and Metabolism of Mount Sinai (USA), there is still no anti-diabetic drug that can regenerate beta cells in diabetics. However, this new breakthrough offers promising results in the case of this disease.
The use of Harmine in combination with other drugs:
A revolutionary drug cocktail that can treat diabetes
Harmine is the drug that can produce new beta cells but in low levels as per a released study in 2015 by Dr. Stewart and his team.
In 2017 was released another study which revealed genetic abnormalities in insulinoma, a pancreatic tumor derived from beta cells and secreting insulin. This study revealed the recipe how to regenerate beta cells.
There is also a second class of drugs that could quickly produce human beta cells administered along with Harmine, according to a recent study released in the Journal Cell Metabolism.
Beta cells replicate at an average rate of 0.2% per day, and when Harmine is given, this rate goes up by 2% per day, and when Harmine is combined with this new drug, this rate increases by 5 to 8% per day.
Dr. Stewart states the following:
“We are very excited about this discovery because, for the first time, we are able to experience a replication rate of human beta cells sufficient to replenish their mass in humans. The next big hurdle is finding a way to deliver them directly to the pancreas. “
But, as per Dr. Stewart, this combination of drugs need further research as their use may reveal side effects for other organs in the body which he did not specify.
Here it is what he states, quoting:
“Now we need to develop methods to deliver these drugs specifically to beta cells in humans (…) We have packages to deliver, but we need a messaging system to send them to the address exact of the beta cell.”